Studies on Stabilization of Variotin

Hiroshi Yamaguchi; Yūya Nakayama; Tomohisa Takita; Ehchirō Akito; Wataru Tanaka; Keihei Ueno; Kōsaku Tahara

doi:10.11554/antibioticsa.12.5_210

Original articles

Studies on Stabilization of Variotin

Hiroshi Yamaguchi, Yūya Nakayama, Tomohisa Takita, Ehchirō Akito, Wataru Tanaka, Keihei Ueno, Kōsaku Tahara

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JOURNAL FREE ACCESS

1959 Volume 12 Issue 5 Pages 210-213

DOI https://gongyi-jschina-com-cn-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.11554/antibioticsa.12.5_210

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Abstract

Variotin is a new antifungal antibiotic discovered by Yonehara, Takeuchi and others^1,2,3). It is a neutral oily substance, produced by Paecilomyces varioti Bainier var. antibioticus.

Notwithstanding its strong activity against pathogenic fungi such as Trichophyton and Blastomyces, industrial production of variotin has been difficult because of low stability. In the studies on stabilization of variotin preparations, following results were obtained.

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