Pharmacological Studies on Variotin

Masayuki Nakatsuka; Harue Aratani; Kōji Ōshita; Hisae Mikawa; Shigenori Mikawa; Akie Tsuchimoto

doi:10.11554/antibioticsa.12.5_214

Original articles

Pharmacological Studies on Variotin

Masayuki Nakatsuka, Harue Aratani, Kōji Ōshita, Hisae Mikawa, Shigenori Mikawa, Akie Tsuchimoto

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JOURNAL FREE ACCESS

1959 Volume 12 Issue 5 Pages 214-221

DOI https://gongyi-jschina-com-cn-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.11554/antibioticsa.12.5_214

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Abstract

Variotin is a new antifungal antibiotic discovered by Sumiki, et al. It is a fragrant white or yellowish oily substance produced by Paecilomyces varioti var. antibioticus. Its chemical characteristics, antibacterial spectrum and clinical effects have been reported, but, in regard to its pharmacological action, it is only reported to have low acute toxicity. Therefore, the authors examined the pharmacological action of variotin and obtained the results described in this paper.

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