Original Articles
Antiprotozoal Antibiotics. II Isolation and Characterization of Trypacidin, A New Antibiotic, Active Against Trypanosoma Cruzi and Toxoplasma Gondii
1963 Volume 16 Issue 4 Pages 157-160
Details
1963 Volume 16 Issue 4 Pages 157-160
Among fungi isolated from the sample of Chinese soil, several cultures exhibiting antiprotozal activity were selected by the specific screening method for antiprotozoal antibiotics1). One of these cultures was identified as Aspergillus fumigatus. We succeeded in isolating an antiprotozoal substance produced by this strain in pure, crystalline form. This antibiotic was confirmed to be a new antibiotic inhibiting Trypanosoma cruzi, and we named it trypacidin. Besides trypacidin, this strain produced at least one other antibiotic active against Bacillus subtilis, though we have not attempted to isolate or characterize this substance. In this paper are described the isolation method of trypacidin as well as some physical, chemical and biological properties of this substance.
