1965 Volume 18 Issue 4 Pages 139-144
Kasugamycin is a new aminoglycosidic antibiotic, effective against a variety of microorganisms, including Piricularia oryzae and Pseudomonas aeruginosa1~3).
The effects of the antibiotic on protein and nucleic acid syntheses were investigated in reference to the mechanism of action. The results are presented in this publication. It was observed that kasugamycin markedly inhibits polyuridylate-directed polyphenylalanine synthesis. The results obtained indicated that it selectively interferes with protein synthesis and the mode of action appears to be similar to that of other aminoglycosidic antibiotics, including streptomycin and kanamycin.
