Annals of the Japanese Respiratory Society
Online ISSN : 2186-5884
Print ISSN : 2186-5876
ISSN-L : 2186-5876
Case Reports
A case of extensive-disease small cell lung cancer with Lambert-Eaton myasthenic syndrome successfully treated with platinum doublet and atezolizumab therapy
Juri Kawasaki Sakae FujimotoHiroyuki KamiyaTakanori Miyoshi
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2025 Volume 14 Issue 3 Pages 118-121

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Abstract

A 67-year-old man was referred to our hospital with anorexia. As a result of detailed examination, he was diagnosed with small cell lung cancer. Additionally, gait impairment from lower limb muscle weakness, elevation of anti-P/Q-type voltage-gated calcium channel antibodies, and a waxing phenomenon during a 30-Hz stimulation on repetitive stimulation test led to a diagnosis of Lambert-Eaton myasthenic syndrome. Four cycles of platinum doublet and atezolizumab therapy resulted in a complete response. His muscle symptoms remained unchanged. Maintenance atezolizumab still continues today without tumor relapse or worsening of muscle symptoms.

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© 2025 The Japanese Respiratory Society
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