Annals of the Japanese Respiratory Society
Online ISSN : 2186-5884
Print ISSN : 2186-5876
ISSN-L : 2186-5876
Case Reports
A case of lung adenocarcinoma complicated by pulmonary hypertrophic osteoarthropathy treated with combination immunotherapy
Kazuki Furuhashi , Hajime Fujimoto, Takaya Hirai, Yurie Kogue, Tatsuki Tsuruga, Tetsu Kobayashi
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Keywords: Non-small cell lung cancer, Pulmonary hypertrophic osteoarthropathy, Immune checkpoint inhibitor, Durvalumab, Tremelimumab
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2025 Volume 14 Issue 3 Pages 127-130

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Abstract

The patient was a 55-year-old man who visited hospital for pain in both knees and lower legs. Physical examination revealed clubbed fingers, and radiographs of the extremities and bone scintigraphy showed findings of periosteogenesis in the long tubular bones. After thorough examinations, he was diagnosed with stageⅣB lung adenocarcinoma complicated by pulmonary hypertrophic osteoarthropathy. He received combined treatment with carboplatin + pemetrexed + durvalumab + tremelimumab as first line therapy. After treatment, the tumor shrank well and the arthritis and other symptoms improved. To the best of our knowledge, there have been no reports about the treatment of lung cancer complicated by pulmonary hypertrophic osteoarthropathy with anti-PD-L1 and anti-CTLA-4 antibodies, and so we report this apparently rare case.

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